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Follow the intergenerational feud between the Joestar Family and various forces of evil, the most prominent of which is Dio Brando and his followers.
Jonathan Joestar's antagonistic relationship with his adopted brother Dio begins a truly bizarre lineage, which is continued by his grandson Joseph.
Joseph Joestar's grandson Jotaro Kujo has a strange new superpower, which turns out to be connected to the reemergence of old foe Dio Brando.
The lineage continues as Joseph Joestar's grandson Jotaro arrives in Morioh to warn his relative Josuke Higashikata of dangerous new Stand users.
In Naples, Italy, the suspected son of Joestar family arch nemesis Dio dreams of becoming a Gang Star so he can bring down the local mafia from within.